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A number of older antibiotic compounds, such as polymyxins, fosfomycin, fusidic acid, sulphonamides, aminoglycosides and chloramphenicol, are re-emerging as valuable alternatives for the treatment of difficult-to-treat infections.
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Chloramphenicol succinate is a prodrug, having no antibacterial activity, which must be hydrolyzed by the liver to chloramphenicol base.
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