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in a carcinogenicity study in which minocycline hcl was orally administered to male and female rats once daily for up to 104 weeks at dosages up to 200 mg kg day, minocycline hcl was associated in both genders with follicular cell tumors of the thyroid gland, including increased incidences of adenomas, carcinomas and the combined incidence of adenomas and carcinomas in males, and adenomas and the combined incidence of adenomas and carcinomas in females.
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